Patho Biochemistry - Publications

Publications

Key Publications (since 2019)

Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system.

Weigert A, Zheng X, Nenzel A, Turkowski K, Günther S, Strack E, Sirait-Fischer E, Elwakeel E, Kur IM, Nikam VS, Valasarajan C, Winter H, Wissgott A, Voswinkel R, Grimminger F, Brüne B, Seeger W, Savai-Pullamsetti S, Savai R.

Nat Commun. 2022 Oct 14; 13 (1): 6078. doi: 10.1038/s41467-022-33458-8.

Phosphatidylserine synthase PTDSS1 shapes the tumor lipidome to maintain tumor-promoting inflammation.

Sekar D, Dillmann C, Sirait-Fischer E, Fink AF, Zivkovic A, Baum N, Strack E, Klatt S, Zukunft S, Wallner S, Descot A, Olesch C, da Silva P, von Knethen A, Schmid T, Grösch S, Savai R, Ferreirós N, Fleming I, Ghosh S, Rothlin CV, Stark H, Medyouf H, Brüne B, Weigert A.

Cancer Res. 2022 Apr 15;82(8):1617-1632. doi: 10.1158/0008-5472.CAN-20-3870.

Disruption of prostaglandin E2 signaling in cancer-associated fibroblasts limits mammary carcinoma growth but promotes metastasis.

Elwakeel E, Brüggemann M, Wagih J, Lityagina O, Elewa MAF, Han Y, Frömel T, Popp R, Nicolas AM, Schreiber Y, Gradhand E, Thomas D, Nüsing R, Steinmetz-Späh J, Savai R, Fokas E, Fleming I, Greten FR, Zarnack K, Brüne B, Weigert A.

Cancer Res. 2022 Apr 1;82(7):1380-1395. doi: 10.1158/0008-5472.CAN-21-2116.

miR-193a-3p increases glycolysis under hypoxia by facilitating Akt phosphorylation and PFKFB3 activation in human macrophages.

Fuhrmann DC, Brüne B.

Cell Mol Life Sci. 2022 Jan 24;79(2):89. doi: 10.1007/s00018-022-04146-z.

Inhibition of mPGES-1 attenuates efficient resolution of acute inflammation by enhancing CX3CL1 expression.

Rappl P, Rösser S, Maul P, Bauer R, Huard A, Schreiber Y, Thomas D, Geisslinger G, Jakobsson PJ, Weigert A, Brüne B, Schmid T.

Cell Death Dis. 2021 Feb 2;12(2):135. doi: 10.1038/s41419-021-03423-2.

Lactate dehydrogenase B regulates macrophage metabolism in the tumor microenvironment.

Frank AC, Raue R, Fuhrmann DC, Sirait-Fischer E, Reuse C, Weigert A, Lütjohann D, Hiller K, Syed SN, Brüne B.

Theranostics. 2021 Jun 4;11(15):7570-7588. doi: 10.7150/thno.58380.

S1PR4 ablation reduces tumor growth and improves chemotherapy via CD8+ T cell expansion.

Olesch C, Sirait-Fischer E, Berkefeld M, Fink AF, Susen RM, Ritter B, Michels BE, Steinhilber D, Greten FR, Savai R, Takeda K, Brüne B, Weigert A.

J Clin Invest. 2020 Oct 1;130(10):5461-5476. doi: 10.1172/JCI136928.

Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis.

Fuhrmann DC, Mondorf A, Beifuß J, Jung M, Brüne B.

Redox Biol. 2020 Sep;36:101670. doi: 10.1016/j.redox.2020.101670.

Translation of TNFAIP2 is tightly controlled by upstream open reading frames.

Scholz A, Rappl P, Bö nger N, Mota AC, Brüne B, Schmid T.

Cell Mol Life Sci. 2020 May;77(10):2017-2027. doi: 10.1007/s00018-019-03265-4.

IL-38 ameliorates skin inflammation and limits IL-17 production from γδ T cells.

Han Y, Mora J, Huard A, da Silva P, Wiechmann S, Putyrski M, Schuster C, Elwakeel E, Lang G, Scholz A, Scholz T, Schmid T, de Bruin N, Billuart P, Sala C, Burkhardt H, Parnham MJ, Ernst A, Brüne B, Weigert A.

Cell Rep. 2019 Apr 16;27(3):835-846.e5. doi: 10.1016/j.celrep.2019.03.082.

Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype.

Frank AC, Ebersberger S, Fink AF, Lampe S, Weigert A, Schmid T, Ebersberger I, Syed SN, Brüne B.

Nat Commun. 2019 Mar 8;10(1):1135. doi: 10.1038/s41467-019-08989-2.

Tolerizing CTL by sustained hepatic PD-L1 expression provides a new therapy approach in mouse sepsis.

Knethen A, Schäfer A, Kuchler L, Knape T, Christen U, Hintermann E, Fißlthaler B, Schröder K, Brandes RP, Genz B, Abshagen K, Pützer BM, Sha LK, Weigert A, Syed SN, Schulz M, Shah AM, Ernst A, Putyrski M, Finkelmeier F, Pesic M, Greten F, Hogardt M, Kempf VAJ, Gunne S, Parnham MJ, Brüne B.

Theranostics. 2019 Mar 16;9(7):2003-2016. doi: 10.7150/thno.28057.

TMEM126B deficiency reduces mitochondrial SDH oxidation by LPS, attenuating HIF-1α stabilization and IL-1β expression.

Fuhrmann DC, Wittig I, Brüne B.

Redox Biol. 2019 Jan;20:204-216. doi: 10.1016/j.redox.2018.10.007.