Publication Lists
For a full list of publications click on the respective names.
Key Publications
RNAi-based ALOX15B silencing augments keratinocyte inflammation in vitro via EGFR/STAT1/JAK1 signalling.
Palmer MA, Kirchhoff R, Buerger C, Benatzy Y, Schebb NH, Brüne B.
Cell Death Dis. 2025 Jan 22;16(1):39. doi: 10.1038/s41419-025-07357-x.
Neutralizing IL-38 activates γδ T cell-dependent antitumor immunity and sensitizes for chemotherapy.
da Silva P, Mora J, You X, Wiechmann S, Putyrski M, Garcia-Pardo J, Kannt A, Ernst A, Bruene B, Weigert A.
J Immunother Cancer. 2024 Aug 28;12(8):e008641. doi: 10.1136/jitc-2023-008641.
Ferroptosis in health and disease.
Berndt C, Alborzinia H, Amen VS, Ayton S, Barayeu U, Bartelt A, Bayir H, Bebber CM, Birsoy K, Böttcher JP, Brabletz S, Brabletz T, Brown AR, Brüne B, Bulli G, Bruneau A, Chen Q, DeNicola GM, Dick TP, Distéfano A, Dixon SJ, Engler JB, Esser-von Bieren J, Fedorova M, Friedmann Angeli JP, Friese MA, Fuhrmann DC, García-Sáez AJ, Garbowicz K, Götz M, Gu W, Hammerich L, Hassannia B, Jiang X, Jeridi A, Kang YP, Kagan VE, Konrad DB, Kotschi S, Lei P, Le Tertre M, Lev S, Liang D, Linkermann A, Lohr C, Lorenz S, Luedde T, Methner A, Michalke B, Milton AV, Min J, Mishima E, Müller S, Motohashi H, Muckenthaler MU, Murakami S, Olzmann JA, Pagnussat G, Pan Z, Papagiannakopoulos T, Pedrera Puentes L, Pratt DA, Proneth B, Ramsauer L, Rodriguez R, Saito Y, Schmidt F, Schmitt C, Schulze A, Schwab A, Schwantes A, Soula M, Spitzlberger B, Stockwell BR, Thewes L, Thorn-Seshold O, Toyokuni S, Tonnus W, Trumpp A, Vandenabeele P, Vanden Berghe T, Venkataramani V, Vogel FCE, von Karstedt S, Wang F, Westermann F, Wientjens C, Wilhelm C, Wölk M, Wu K, Yang X, Yu F, Zou Y, Conrad M.
Redox Biol. 2024 Sep;75:103211. doi: 10.1016/j.redox.2024.103211.
ALOX15B controls macrophage cholesterol homeostasis via lipid peroxidation, ERK1/2 and SREBP2.
Benatzy Y, Palmer MA, Lütjohann D, Ohno RI, Kampschulte N, Schebb NH, Fuhrmann DC, Snodgrass RG, Brüne B.
Redox Biol. 2024 Jun;72:103149. doi: 10.1016/j.redox.2024.103149
Tumor associated macrophages transfer ceruloplasmin mRNA to fibrosarcoma cells and protect them from ferroptosis.
Schwantes A, Wickert A, Becker S, Baer PC, Weigert A, Brüne B, Fuhrmann DC.
Redox Biol. 2024 May;71:103093. doi: 10.1016/j.redox.2024.103093
Hypoxia-altered cholesterol homeostasis enhances the expression of interferon-stimulated genes upon SARS-CoV-2 infections in monocytes.
Bauer R, Meyer SP, Raue R, Palmer MA, Guerrero Ruiz VM, Cardamone G, Rösser S, Heffels M, Roesmann F, Wilhelm A, Lütjohann D, Zarnack K, Fuhrmann DC, Widera M, Schmid T, Brüne B.
Front Immunol. 2023 Jun 12;14:1121864. doi: 10.3389/fimmu.2023.1121864
Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system.
Weigert A, Zheng X, Nenzel A, Turkowski K, Günther S, Strack E, Sirait-Fischer E, Elwakeel E, Kur IM, Nikam VS, Valasarajan C, Winter H, Wissgott A, Voswinkel R, Grimminger F, Brüne B, Seeger W, Savai-Pullamsetti S, Savai R.
Nat Commun. 2022 Oct 14; 13 (1): 6078. doi: 10.1038/s41467-022-33458-8.
Phosphatidylserine synthase PTDSS1 shapes the tumor lipidome to maintain tumor-promoting inflammation.
Sekar D, Dillmann C, Sirait-Fischer E, Fink AF, Zivkovic A, Baum N, Strack E, Klatt S, Zukunft S, Wallner S, Descot A, Olesch C, da Silva P, von Knethen A, Schmid T, Grösch S, Savai R, Ferreirós N, Fleming I, Ghosh S, Rothlin CV, Stark H, Medyouf H, Brüne B, Weigert A.
Cancer Res. 2022 Apr 15;82(8):1617-1632. doi: 10.1158/0008-5472.CAN-20-3870.
Disruption of prostaglandin E2 signaling in cancer-associated fibroblasts limits mammary carcinoma growth but promotes metastasis.
Elwakeel E, Brüggemann M, Wagih J, Lityagina O, Elewa MAF, Han Y, Frömel T, Popp R, Nicolas AM, Schreiber Y, Gradhand E, Thomas D, Nüsing R, Steinmetz-Späh J, Savai R, Fokas E, Fleming I, Greten FR, Zarnack K, Brüne B, Weigert A.
Cancer Res. 2022 Apr 1;82(7):1380-1395. doi: 10.1158/0008-5472.CAN-21-2116.
miR-193a-3p increases glycolysis under hypoxia by facilitating Akt phosphorylation and PFKFB3 activation in human macrophages.
Fuhrmann DC, Brüne B.
Cell Mol Life Sci. 2022 Jan 24;79(2):89. doi: 10.1007/s00018-022-04146-z.
Inhibition of mPGES-1 attenuates efficient resolution of acute inflammation by enhancing CX3CL1 expression.
Rappl P, Rösser S, Maul P, Bauer R, Huard A, Schreiber Y, Thomas D, Geisslinger G, Jakobsson PJ, Weigert A, Brüne B, Schmid T.
Cell Death Dis. 2021 Feb 2;12(2):135. doi: 10.1038/s41419-021-03423-2.
Lactate dehydrogenase B regulates macrophage metabolism in the tumor microenvironment.
Frank AC, Raue R, Fuhrmann DC, Sirait-Fischer E, Reuse C, Weigert A, Lütjohann D, Hiller K, Syed SN, Brüne B.
Theranostics. 2021 Jun 4;11(15):7570-7588. doi: 10.7150/thno.58380.
S1PR4 ablation reduces tumor growth and improves chemotherapy via CD8+ T cell expansion.
Olesch C, Sirait-Fischer E, Berkefeld M, Fink AF, Susen RM, Ritter B, Michels BE, Steinhilber D, Greten FR, Savai R, Takeda K, Brüne B, Weigert A.
J Clin Invest. 2020 Oct 1;130(10):5461-5476. doi: 10.1172/JCI136928.
Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis.
Fuhrmann DC, Mondorf A, Beifuß J, Jung M, Brüne B.
Redox Biol. 2020 Sep;36:101670. doi: 10.1016/j.redox.2020.101670.
Translation of TNFAIP2 is tightly controlled by upstream open reading frames.
Scholz A, Rappl P, Bö nger N, Mota AC, Brüne B, Schmid T.
Cell Mol Life Sci. 2020 May;77(10):2017-2027. doi: 10.1007/s00018-019-03265-4.